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Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair.
Harnicek, Dominique; Kampmann, Eric; Lauber, Kirsten; Hennel, Roman; Cardoso Martins, Ana Sofia; Guo, Yang; Belka, Claus; Mörtl, Simone; Gallmeier, Eike; Kanaar, Roland; Mansmann, Ulrich; Hucl, Tomas; Lindner, Lars H; Hiddemann, Wolfgang; Issels, Rolf D.
Affiliation
  • Harnicek D; Hämatologikum of the Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.
  • Kampmann E; Department of Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany.
  • Lauber K; Department of Radiation Oncology, University Hospital Grosshadern, University of Munich, Munich, Germany.
  • Hennel R; Department of Radiation Oncology, University Hospital Grosshadern, University of Munich, Munich, Germany.
  • Cardoso Martins AS; Hämatologikum of the Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.
  • Guo Y; Department of Medicine II, University Hospital Grosshadern, University of Munich, Munich, Germany.
  • Belka C; Department of Radiation Oncology, University Hospital Grosshadern, University of Munich, Munich, Germany.
  • Mörtl S; Institute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Gallmeier E; Department of Internal Medicine, Philipps University of Marburg, Marburg, Germany.
  • Kanaar R; Department of Genetics, Cancer Genomics Netherlands, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Mansmann U; Department of Radiation Oncology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Hucl T; Institute of Medical Informatics, Biostatistics, and Epidemiology, Campus Grosshadern, University of Munich, Munich, Germany.
  • Lindner LH; Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
  • Hiddemann W; Department of Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany.
  • Issels RD; Department of Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany.
Int J Cancer ; 139(2): 467-79, 2016 07 15.
Article in En | MEDLINE | ID: mdl-26933761

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Agents, Alkylating / BRCA2 Protein / Tetrahydroisoquinolines / Dioxoles / Recombinational DNA Repair / Hyperthermia, Induced Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Int J Cancer Year: 2016 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Agents, Alkylating / BRCA2 Protein / Tetrahydroisoquinolines / Dioxoles / Recombinational DNA Repair / Hyperthermia, Induced Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Int J Cancer Year: 2016 Document type: Article Affiliation country: Country of publication: