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PK/PD analysis of a novel pH-dependent antigen-binding antibody using a dynamic antibody-antigen binding model.
Haraya, Kenta; Tachibana, Tatsuhiko; Iwayanagi, Yuki; Maeda, Atsuhiko; Ozeki, Kazuhisa; Nezu, Junichi; Ishigai, Masaki; Igawa, Tomoyuki.
Affiliation
  • Haraya K; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #04-11 to 17 Synapse, 138623, Singapore. Electronic address: haraya.kenta@chugai-pharm.co.jp.
  • Tachibana T; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #04-11 to 17 Synapse, 138623, Singapore.
  • Iwayanagi Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Maeda A; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Ozeki K; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Nezu J; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #04-11 to 17 Synapse, 138623, Singapore.
  • Ishigai M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Igawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
Drug Metab Pharmacokinet ; 31(2): 123-32, 2016 Apr.
Article in En | MEDLINE | ID: mdl-26944099
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Monoclonal / Antigen-Antibody Reactions / Antigens Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2016 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Monoclonal / Antigen-Antibody Reactions / Antigens Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2016 Document type: Article Country of publication: