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Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).
Schwarz, Theresa; Montanari, Floriane; Cseke, Anna; Wlcek, Katrin; Visvader, Lene; Palme, Sarah; Chiba, Peter; Kuchler, Karl; Urban, Ernst; Ecker, Gerhard F.
Affiliation
  • Schwarz T; Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
  • Montanari F; Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
  • Cseke A; Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
  • Wlcek K; Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
  • Visvader L; Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
  • Palme S; Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
  • Chiba P; Department of Medicinal Chemistry, Medical University Vienna, Währingerstraße 10, 1090, Vienna, Austria.
  • Kuchler K; Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University Vienna, Dr. Bohr-Gasse 9/2, 1030, Vienna, Austria.
  • Urban E; Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
  • Ecker GF; Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria. gerhard.f.ecker@univie.ac.at.
ChemMedChem ; 11(12): 1380-94, 2016 06 20.
Article in En | MEDLINE | ID: mdl-26970257
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propafenone / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / ATP Binding Cassette Transporter, Subfamily G, Member 2 / Neoplasm Proteins Limits: Female / Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2016 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propafenone / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / ATP Binding Cassette Transporter, Subfamily G, Member 2 / Neoplasm Proteins Limits: Female / Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2016 Document type: Article Affiliation country: Country of publication: