[Significance of Th17/Treg imbalance in children with primary immune thrombocytopenia].
Zhongguo Dang Dai Er Ke Za Zhi
; 18(3): 238-42, 2016 Mar.
Article
in Zh
| MEDLINE
| ID: mdl-26975822
ABSTRACT
OBJECTIVE:
To investigate the significance of Th17/Treg imbalance in the development and treatment of primary immune thrombocytopenia (ITP) in children.METHODS:
Thirty-two children diagnosed with ITP between May and August, 2015 and 22 healthy children were enrolled. Flow cytometry was used to determine the Th17/Treg ratio in peripheral blood of healthy children and children with ITP before and after treatment with immunoglobulin.RESULTS:
Compared with the patients with ITP before treatment, the healthy children and the patients treated with immunoglobulin had a significantly lower percentage of Th17 cells in CD4+ T cells, a significantly lower Th17/Treg ratio, and a significantly higher percentage of Treg cells in CD4+ T cells in peripheral blood (P<0.05). In the 32 ITP children treated with immunoglobulin, 20 had complete response, 4 had response, and 8 had no response. The patients with complete response had a significantly lower percentage of Th17 cells in CD4+ T cells and a significantly lower Th17/Treg ratio in peripheral blood than the patients without response (P<0.05).CONCLUSIONS:
The Th17/Treg imbalance can be found in children with ITP. Immunoglobulin can improve the cellular immune function by regulation of the Th17/Treg ratio. The Th17/Treg ratio may serve as an indicator for assessing the therapeutic effects of ITP.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Purpura, Thrombocytopenic, Idiopathic
/
T-Lymphocytes, Regulatory
/
Th17 Cells
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Zh
Journal:
Zhongguo Dang Dai Er Ke Za Zhi
Year:
2016
Document type:
Article
Affiliation country: