Imiquimod treatment for Equus caballus papillomavirus infection in equine aural plaques.
Vet Dermatol
; 27(3): 175-e44, 2016 Jun.
Article
in En
| MEDLINE
| ID: mdl-27109291
ABSTRACT
BACKGROUND:
Aural plaques are a dermatopathy associated with Equus caballus papillomavirus (EcPV). This disease affects horses of all ages, genders and breeds, and causes sensitivity of the ears. HYPOTHESIS/OBJECTIVES:
The aim of this study was to evaluate the clinical efficacy of 5% imiquimod cream for the treatment of aural plaques and to compare the PCR detection of EcPV 3, 4, 5 and 6 before and after treatment. ANIMALS Eight horses diagnosed with aural plaques (14 ears) were used. Three mares with unilateral aural plaques were used as untreated controls.METHODS:
Imiquimod cream was applied every 48 h until complete resolution of the aural plaques was observed. Animals were evaluated clinically for 180 days after the end of treatment. PCR for detecting EcPV 3, 4, 5 and 6 was performed using aural plaque biopsies collected before and at 90 days after the end of treatment.RESULTS:
Clinical resolution was observed in 93% of the treated ears. Imiquimod treatment promoted the clearance of EcPV in 71.4% of the treated ears. Clinical remission of the aural plaques and changes in EcPV DNA positivity between the first and second biopsies were not observed in the control group. In 75% of horses, sedation was required in order to carry out pretreatment cleaning.CONCLUSIONS:
The results of this study support the hypothesis that 5% imiquimod cream may be used as an effective treatment for aural plaques in horses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Papillomaviridae
/
Skin Diseases, Viral
/
Papillomavirus Infections
/
Ear Auricle
/
Aminoquinolines
/
Horse Diseases
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Vet Dermatol
Journal subject:
DERMATOLOGIA
/
MEDICINA VETERINARIA
Year:
2016
Document type:
Article
Affiliation country: