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Acute Administration of Diazepam Provokes Redox Homeostasis Imbalance in the Rat Brain: Prevention by Simvastatin.
Eger, Guilherme André; Ferreira, Vinícius Vialle; Batista, Camila Ribeiro; Bonde, Henrique LuisPetrek; de Lima, Daniela Delwing; Rodrigues, André Felipe; da Cruz, José Geraldo Pereira; Magro, Débora Delwing Dal.
Affiliation
  • Eger GA; Department of Medicine, Regional University of Blumenau, Rua Antônio da Veiga, 140, Blumenau, SC, Brazil.
  • Ferreira VV; Department of Medicine, Regional University of Blumenau, Rua Antônio da Veiga, 140, Blumenau, SC, Brazil.
  • Batista CR; Department of Medicine, Regional University of Blumenau, Rua Antônio da Veiga, 140, Blumenau, SC, Brazil.
  • Bonde HL; Department of Medicine, Regional University of Blumenau, Rua Antônio da Veiga, 140, Blumenau, SC, Brazil.
  • de Lima DD; Department of Medicine, University of Joinville Region, Campus Universitário, Bairro Bom Retiro, Joinville, SC, Brazil.
  • Rodrigues AF; Department of Natural Sciences, Regional University of Blumenau, Rua Antônio da Veiga, Blumenau, SC, Brazil.
  • da Cruz JG; Department of Natural Sciences, Regional University of Blumenau, Rua Antônio da Veiga, Blumenau, SC, Brazil.
  • Magro DD; Department of Natural Sciences, Regional University of Blumenau, Rua Antônio da Veiga, Blumenau, SC, Brazil. deboradelwing@furb.br.
J Biochem Mol Toxicol ; 30(10): 506-512, 2016 Oct.
Article in En | MEDLINE | ID: mdl-27111380
We investigated the effects of acute diazepam (DZP) administration on thiobarbituric acid-reactive substance (TBARS) levels, protein carbonyl content, and on the activities of the antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase in the brain of rats. Additionally, we investigated the antioxidant role of chronic pretreatment with simvastatin on the effects provoked by DZP. Simvastatin was administered (1 or 10 mg/kg by oral gavage) for 30 days. On the 30th day of treatment, groups were randomized and DZP was administered (0.5 or 1.0 mg/kg by intraperitoneal injection). Control groups received saline. Results showed that DZP enhanced TBARS levels and protein carbonyl content and altered enzymatic activity in the brain of rats. Simvastatin prevented most of the alterations caused by DZP on the oxidative stress parameters. Data indicate that DZP administration causes an oxidative imbalance in the brain areas studied; however, in the presence of simvastatin, some of these alterations in oxidative stress were prevented.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / Simvastatin / Diazepam / Hypnotics and Sedatives / Anticholesteremic Agents Limits: Animals Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2016 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / Simvastatin / Diazepam / Hypnotics and Sedatives / Anticholesteremic Agents Limits: Animals Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2016 Document type: Article Affiliation country: Country of publication: