Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity.
Science
; 244(4905): 697-9, 1989 May 12.
Article
in En
| MEDLINE
| ID: mdl-2717946
ABSTRACT
Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
/
Aminoglycosides
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
Science
Year:
1989
Document type:
Article