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Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation.
Gong, Qian; Hazen, Meredith; Marshall, Brett; Crowell, Susan R; Ou, Qinglin; Wong, Athena W; Phung, Wilson; Vernes, Jean-Michel; Meng, Y Gloria; Tejada, Max; Andersen, Dana; Kelley, Robert F.
Affiliation
  • Gong Q; a Department of Immunology , Genentech Inc. , South San Francisco , CA , USA.
  • Hazen M; b Department of Antibody Engineering , Genentech Inc. , South San Francisco , CA , USA.
  • Marshall B; c Department of Biological Technologies , Genentech Inc. , South San Francisco , CA , USA.
  • Crowell SR; d Department of Preclinical and Translational Pharmacokinetics , Genentech Inc. , South San Francisco , CA , USA.
  • Ou Q; a Department of Immunology , Genentech Inc. , South San Francisco , CA , USA.
  • Wong AW; e Department of Early Stage Cell Culture , Genentech Inc. , South San Francisco , CA , USA.
  • Phung W; f Department of Protein Chemistry , Genentech Inc. , South San Francisco CA , USA.
  • Vernes JM; g Department of Biochemical and Cellular Pharmacology , Genentech Inc. , South San Francisco , CA , USA.
  • Meng YG; g Department of Biochemical and Cellular Pharmacology , Genentech Inc. , South San Francisco , CA , USA.
  • Tejada M; c Department of Biological Technologies , Genentech Inc. , South San Francisco , CA , USA.
  • Andersen D; h Department of Pharmaceutical Development , Genentech Inc. , South San Francisco , CA , USA.
  • Kelley RF; i Department of Drug Delivery , Genentech Inc. , South San Francisco , CA , USA.
MAbs ; 8(6): 1098-106, 2016.
Article in En | MEDLINE | ID: mdl-27216702
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Antigens, CD20 / Fucose / Antibodies, Monoclonal / Antibody-Dependent Cell Cytotoxicity Limits: Animals / Female / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2016 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Antigens, CD20 / Fucose / Antibodies, Monoclonal / Antibody-Dependent Cell Cytotoxicity Limits: Animals / Female / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2016 Document type: Article Affiliation country: Country of publication: