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Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases.
Ni, Jing; Ramkissoon, Shakti H; Xie, Shaozhen; Goel, Shom; Stover, Daniel G; Guo, Hanbing; Luu, Victor; Marco, Eugenio; Ramkissoon, Lori A; Kang, Yun Jee; Hayashi, Marika; Nguyen, Quang-De; Ligon, Azra H; Du, Rose; Claus, Elizabeth B; Alexander, Brian M; Yuan, Guo-Cheng; Wang, Zhigang C; Iglehart, J Dirk; Krop, Ian E; Roberts, Thomas M; Winer, Eric P; Lin, Nancy U; Ligon, Keith L; Zhao, Jean J.
Affiliation
  • Ni J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Ramkissoon SH; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
  • Xie S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Goel S; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Stover DG; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Guo H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
  • Luu V; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Marco E; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Ramkissoon LA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Kang YJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Hayashi M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
  • Nguyen QD; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Ligon AH; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
  • Du R; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Claus EB; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Alexander BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Yuan GC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Wang ZC; Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Iglehart JD; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Krop IE; Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Roberts TM; Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Winer EP; School of Public Health, Yale University, New Haven, Connecticut, USA.
  • Lin NU; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Ligon KL; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Zhao JJ; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Nat Med ; 22(7): 723-6, 2016 07.
Article in En | MEDLINE | ID: mdl-27270588
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Breast Neoplasms / Morpholines / Apoptosis / Multiprotein Complexes / TOR Serine-Threonine Kinases / Everolimus / Phosphoinositide-3 Kinase Inhibitors / Aminopyridines / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2016 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Breast Neoplasms / Morpholines / Apoptosis / Multiprotein Complexes / TOR Serine-Threonine Kinases / Everolimus / Phosphoinositide-3 Kinase Inhibitors / Aminopyridines / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2016 Document type: Article Affiliation country: Country of publication: