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Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Hewitt, Ellen; Pitcher, Thomas; Rizoska, Biljana; Tunblad, Karin; Henderson, Ian; Sahlberg, Britt-Louise; Grabowska, Urszula; Classon, Björn; Edenius, Charlotte; Malcangio, Marzia; Lindström, Erik.
Affiliation
  • Hewitt E; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Pitcher T; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Rizoska B; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Tunblad K; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Henderson I; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Sahlberg BL; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Grabowska U; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Classon B; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Edenius C; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Malcangio M; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.).
  • Lindström E; Medivir AB, Huddinge, Sweden (E.H., B.R., K.T., I.H., B.-L.S., U.G., B.C., C.E., E.L.); King´s College London, London, United Kingdom (T.P., M.M.) Erik.Lindstrom@albireopharma.com.
J Pharmacol Exp Ther ; 358(3): 387-96, 2016 09.
Article in En | MEDLINE | ID: mdl-27335437
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Cathepsins / Cyclohexanecarboxylic Acids / Dipeptides / Pregabalin / Gamma-Aminobutyric Acid / Amines / Hyperalgesia / Neuralgia Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2016 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Cathepsins / Cyclohexanecarboxylic Acids / Dipeptides / Pregabalin / Gamma-Aminobutyric Acid / Amines / Hyperalgesia / Neuralgia Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2016 Document type: Article Country of publication: