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Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors.
Elgaher, Walid A M; Sharma, Kamal K; Haupenthal, Jörg; Saladini, Francesco; Pires, Manuel; Real, Eleonore; Mély, Yves; Hartmann, Rolf W.
Affiliation
  • Elgaher WA; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); and Pharmaceutical and Medicinal Chemistry, Saarland University , Campus E8.1, 66123 Saarbrücken, Germany.
  • Sharma KK; Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, UMR 7213 CNRS, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
  • Haupenthal J; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); and Pharmaceutical and Medicinal Chemistry, Saarland University , Campus E8.1, 66123 Saarbrücken, Germany.
  • Saladini F; Department of Medical Biotechnologies, University of Siena , Viale Mario Bracci 16, 53100 Siena, Italy.
  • Pires M; Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, UMR 7213 CNRS, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
  • Real E; Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, UMR 7213 CNRS, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
  • Mély Y; Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, UMR 7213 CNRS, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
  • Hartmann RW; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); and Pharmaceutical and Medicinal Chemistry, Saarland University , Campus E8.1, 66123 Saarbrücken, Germany.
J Med Chem ; 59(15): 7212-22, 2016 Aug 11.
Article in En | MEDLINE | ID: mdl-27339173
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / DNA-Directed RNA Polymerases / Carboxylic Acids / RNA-Directed DNA Polymerase / Enzyme Inhibitors / Drug Discovery / Anti-Bacterial Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / DNA-Directed RNA Polymerases / Carboxylic Acids / RNA-Directed DNA Polymerase / Enzyme Inhibitors / Drug Discovery / Anti-Bacterial Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: Country of publication: