SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF NEW MANDELATE IONIC LIQUIDS.
Acta Pol Pharm
; 73(3): 705-15, 2016.
Article
in En
| MEDLINE
| ID: mdl-27476289
ABSTRACT
Novel mandelate ionic liquids with quartenary ammonium cations were synthesized and characterized. The compounds exhibit antimicrobial activity and the most potent one is of similar efficacy against Gram+ bacteria as its counterpart chloride. On the other hand, the mandelates are much less active against Gram-bacteria and fungi. QSAR models suggest that, with respect to cation, their potency depends on lipophilicity. The synthesized ionic liquids are also quite cytotoxic against mammalian cells.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ionic Liquids
/
Mandelic Acids
/
Anti-Infective Agents
Language:
En
Journal:
Acta Pol Pharm
Year:
2016
Document type:
Article