[Role of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease].
Sheng Li Xue Bao
; 68(4): 517-24, 2016 Aug 25.
Article
in Zh
| MEDLINE
| ID: mdl-27546511
ABSTRACT
Calcium overload is one of the important mechanisms of cardiovascular disease. Endoplasmic reticulum is an important organelle which regulates intracellular calcium homeostasis by uptake, storage and mobilization of calcium. So it plays a critical role in regulation of intracellular calcium homeostasis. Endoplasmic reticulum, which is widely distributed in cytoplasm, has a large number of membrane junction sites. Recent studies have reported that these junction sites are distributed on plasma membrane and organelle membranes (mitochondria, lysosomes, Golgi apparatus, etc.), separately. They could form complexes to regulate calcium transport. In this review, we briefly outlined the recent research progresses of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease, which may offer a new strategy for prevention and treatment of cardiovascular disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Cell Membrane
/
Endoplasmic Reticulum
/
Homeostasis
Limits:
Humans
Language:
Zh
Journal:
Sheng Li Xue Bao
Year:
2016
Document type:
Article
Affiliation country: