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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.
Woodhead, Jeffrey L; Brock, William J; Roth, Sharin E; Shoaf, Susan E; Brouwer, Kim L R; Church, Rachel; Grammatopoulos, Tom N; Stiles, Linsey; Siler, Scott Q; Howell, Brett A; Mosedale, Merrie; Watkins, Paul B; Shoda, Lisl K M.
Affiliation
  • Woodhead JL; DILIsym Services, Inc, Research Triangle Park, North Carolina.
  • Brock WJ; Otsuka Pharmaceutical Development & Commercialization, Brock Scientific Consulting, Montgomery Village, Rockville, Maryland.
  • Roth SE; Otsuka Pharmaceutical Development & Commercialization, Rockville, Maryland.
  • Shoaf SE; Otsuka Pharmaceutical Development & Commercialization, Rockville, Maryland.
  • Brouwer KL; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • Church R; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • Grammatopoulos TN; UNC Institute for Drug Safety Sciences, University of North Carolina at Chapel Hill, Research Triangle Park, North Carolina.
  • Stiles L; BioEnergetics LLC, Boston, Massachusetts.
  • Siler SQ; BioEnergetics LLC, Boston, Massachusetts.
  • Howell BA; DILIsym Services, Inc, Research Triangle Park, North Carolina.
  • Mosedale M; DILIsym Services, Inc, Research Triangle Park, North Carolina.
  • Watkins PB; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • Shoda LK; UNC Institute for Drug Safety Sciences, University of North Carolina at Chapel Hill, Research Triangle Park, North Carolina.
Toxicol Sci ; 155(1): 61-74, 2017 01.
Article in En | MEDLINE | ID: mdl-27655350
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzazepines / Chemical and Drug Induced Liver Injury / Antidiuretic Hormone Receptor Antagonists / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2017 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzazepines / Chemical and Drug Induced Liver Injury / Antidiuretic Hormone Receptor Antagonists / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2017 Document type: Article Country of publication: