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Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.
Göllner, Stefanie; Oellerich, Thomas; Agrawal-Singh, Shuchi; Schenk, Tino; Klein, Hans-Ulrich; Rohde, Christian; Pabst, Caroline; Sauer, Tim; Lerdrup, Mads; Tavor, Sigal; Stölzel, Friedrich; Herold, Sylvia; Ehninger, Gerhard; Köhler, Gabriele; Pan, Kuan-Ting; Urlaub, Henning; Serve, Hubert; Dugas, Martin; Spiekermann, Karsten; Vick, Binje; Jeremias, Irmela; Berdel, Wolfgang E; Hansen, Klaus; Zelent, Arthur; Wickenhauser, Claudia; Müller, Lutz P; Thiede, Christian; Müller-Tidow, Carsten.
Affiliation
  • Göllner S; Department of Medicine IV, Hematology and Oncology, University Hospital of Halle (Saale), Halle (Saale), Germany.
  • Oellerich T; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany.
  • Agrawal-Singh S; German Cancer Consortium (DKTK), Heidelberg, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Schenk T; Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark.
  • Klein HU; Institute of Cancer Research (ICR), Molecular Pathology, London, UK.
  • Rohde C; Institute of Medical Informatics, University Hospital of Münster, Münster, Germany.
  • Pabst C; Department of Medicine IV, Hematology and Oncology, University Hospital of Halle (Saale), Halle (Saale), Germany.
  • Sauer T; Department of Medicine IV, Hematology and Oncology, University Hospital of Halle (Saale), Halle (Saale), Germany.
  • Lerdrup M; Department of Medicine A, Hematology and Oncology, University Hospital of Münster, Münster, Germany.
  • Tavor S; Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark.
  • Stölzel F; Goldyne Savad Institute of Gene Therapy, Jerusalem, Israel.
  • Herold S; Department of Medicine, Molecular Hematology, University Hospital Carl Gustav Carus, Dresden, Germany.
  • Ehninger G; Department of Medicine, Molecular Hematology, University Hospital Carl Gustav Carus, Dresden, Germany.
  • Köhler G; Department of Medicine, Molecular Hematology, University Hospital Carl Gustav Carus, Dresden, Germany.
  • Pan KT; Gerhard Domagk Institute of Pathology, University of Münster, Münster, Germany.
  • Urlaub H; Bioanalytical Mass Spectrometry Group, Max Plank Institute for Biophysical Chemistry, Goettingen, Germany.
  • Serve H; Bioanalytical Mass Spectrometry Group, Max Plank Institute for Biophysical Chemistry, Goettingen, Germany.
  • Dugas M; Bioanalytics, Institute for Clinical Chemistry, University Medical Center Göttingen, Germany.
  • Spiekermann K; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany.
  • Vick B; German Cancer Consortium (DKTK), Heidelberg, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Jeremias I; Institute of Medical Informatics, University Hospital of Münster, Münster, Germany.
  • Berdel WE; German Cancer Consortium (DKTK), Heidelberg, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hansen K; Department of Medicine III, University Hospital of Munich, Munich, Germany.
  • Zelent A; German Cancer Consortium (DKTK), Heidelberg, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Wickenhauser C; Research Unit Gene Vectors, Helmholtz Center Munich, Munich, Germany.
  • Müller LP; German Cancer Consortium (DKTK), Heidelberg, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Thiede C; Research Unit Gene Vectors, Helmholtz Center Munich, Munich, Germany.
  • Müller-Tidow C; Department of Medicine A, Hematology and Oncology, University Hospital of Münster, Münster, Germany.
Nat Med ; 23(1): 69-78, 2017 01.
Article in En | MEDLINE | ID: mdl-27941792
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Leukemia, Myeloid, Acute / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Enhancer of Zeste Homolog 2 Protein Limits: Aged80 Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2017 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Leukemia, Myeloid, Acute / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Enhancer of Zeste Homolog 2 Protein Limits: Aged80 Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2017 Document type: Article Affiliation country: Country of publication: