CD40 signaling and hepatic steatosis: Unanticipated links.
Clin Res Hepatol Gastroenterol
; 41(4): 357-369, 2017 Sep.
Article
in En
| MEDLINE
| ID: mdl-27989689
ABSTRACT
Obesity predisposes to an increased risk of nonalcoholic fatty liver disease (NAFLD). Hepatic steatosis is the key pathological feature of NAFLD and has emerged as a metabolic disorder in which innate and adaptive arms of the immune response play a central role in disease pathogenesis. Recent studies have revealed unexpected relationships between CD40 signaling and hepatic steatosis in high fat diet rodent models. CD154, the ligand of CD40, is a mediator of inflammation and controls several critical events of innate and adaptive immune responses. In the light of these reports, we discuss potential links between CD40 signaling and hepatic steatosis in NAFLD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
CD40 Antigens
/
Non-alcoholic Fatty Liver Disease
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Clin Res Hepatol Gastroenterol
Year:
2017
Document type:
Article
Affiliation country: