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Intestinal Enterobacteriaceae that Protect Nematodes from the Effects of Benzimidazoles.
Whittaker, John H; Robertson, Alan P; Kimber, Michael J; Day, Tim A; Carlson, Steve A.
Affiliation
  • Whittaker JH; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
  • Robertson AP; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
  • Kimber MJ; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
  • Day TA; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
  • Carlson SA; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
J Bacteriol Parasitol ; 7(5)2016 Oct.
Article in En | MEDLINE | ID: mdl-28066686
The objective of this study was to investigate an interaction between nematodes and gut Enterobacteriaceae that use benzimidazoles as a carbon source. By addressing this objective, we identified an anthelmintic resistance-like mechanism for gastrointestinal nematodes. We isolated 30 gut bacteria (family Enterobacteriaceae) that subsist on and putatively catabolize benzimidazole-class anthelmintics. C. elegans was protected from the effects of benzimidazoles when co-incubated with these Enterobacteriaceae that also protect adult ascarids from the effects of albendazole. This bacterial phenotype represents a novel mechanism by which gastrointestinal nematodes are potentially spared from the effects of benzimidazoles, without any apparent fitness cost to the parasite.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Bacteriol Parasitol Year: 2016 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Bacteriol Parasitol Year: 2016 Document type: Article Affiliation country: Country of publication: