Inhalable oridonin-loaded poly(lactic-<i>co</i>-glycolic)acid large porous microparticles for <i>in situ</i> treatment of primary non-small cell lung cancer.

Zhu, Lifei; Li, Miao; Liu, Xiaoyan; Du, Lina; Jin, Yiguang

Inhalable oridonin-loaded poly(lactic-co-glycolic)acid large porous microparticles for in situ treatment of primary non-small cell lung cancer.

Zhu, Lifei; Li, Miao; Liu, Xiaoyan; Du, Lina; Jin, Yiguang.

Affiliation

Zhu L; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China; Anhui Medical University, Hefei 230001, China; Department of Pharmacy, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
Li M; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Liu X; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Du L; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Jin Y; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China; Anhui Medical University, Hefei 230001, China.

Acta Pharm Sin B ; 7(1): 80-90, 2017 Jan.

Article in En | MEDLINE | ID: mdl-28119812

Key words

BSA, bovine serum albumin; DAB, 3,3Ê¹-diaminobenzidine; DAPI, 4Ê¹,6-diamidino-2-phenylindole; DPI, dry powder inhalation; EGFR, epidermal growth factor receptor; FPF, fine particle fraction; HPLC, high performance liquid chromatography; HRP, horseradish peroxidase; LPMP, large porous microparticle; Large porous microparticle; NSCLC, non-small cell lung cancer; Non-small cell lung cancer; Oridonin; PLGA, poly(lactic-co-glycolic)acid; PVA, polyvinyl alcohol; Poly(lactic-co-glycolic)acid; Pulmonary delivery; SEM, scanning electron microscopy; SLF, simulated lung fluid; TCM, traditional Chinese medicine; XRD, X-ray diffraction; qPCR, quantitative polymerase chain reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Acta Pharm Sin B Year: 2017 Document type: Article Affiliation country:

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