Towards an understanding of Salmonella enterica serovar Typhimurium persistence in swine.
Anim Health Res Rev
; 17(2): 159-168, 2016 12.
Article
in En
| MEDLINE
| ID: mdl-28155802
ABSTRACT
Salmonella enterica is an important food borne pathogen that is frequently carried by swine. Carrier animals pose a food safety risk because they can transmit S. enterica to finished food products in the processing plant or by contamination of the environment. Environmental contamination has become increasingly important as non-animal foods (plant-based) have been implicated as sources of S. enterica. The prevalence of S. enterica in swine is high and yet carrier animals remain healthy. S. enterica has developed a highly sophisticated set of virulence factors that allow it to adapt to host environments and to cause disease. It is assumed that S. enterica also has developed unique ways to maintain itself in animals and yet not cause disease. Here we describe our research to understand persistence. Specifically, data are presented that demonstrates that detection of most carrier animals requires specific stresses that cause S. enterica to be shed from pigs. As well, we describe a phenotypic phase variation process that appears to be linked to the carrier state and a complex set of factors that control phenotypic phase variation. Finally, we describe how the composition of the gut bacterial microbiome may contribute to persistence and at the least how S. enterica might alter the composition of the gut bacterial microbiome.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salmonella Infections, Animal
/
Salmonella typhimurium
/
Swine Diseases
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Anim Health Res Rev
Journal subject:
MEDICINA VETERINARIA
Year:
2016
Document type:
Article
Affiliation country: