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FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression.
Heuer, Timothy S; Ventura, Richard; Mordec, Kasia; Lai, Julie; Fridlib, Marina; Buckley, Douglas; Kemble, George.
Affiliation
  • Heuer TS; 3-V Biosciences, Menlo Park, CA, USA. Electronic address: tim@celldesignlabs.com.
  • Ventura R; 3-V Biosciences, Menlo Park, CA, USA.
  • Mordec K; 3-V Biosciences, Menlo Park, CA, USA.
  • Lai J; 3-V Biosciences, Menlo Park, CA, USA.
  • Fridlib M; 3-V Biosciences, Menlo Park, CA, USA.
  • Buckley D; 3-V Biosciences, Menlo Park, CA, USA.
  • Kemble G; 3-V Biosciences, Menlo Park, CA, USA.
EBioMedicine ; 16: 51-62, 2017 Feb.
Article in En | MEDLINE | ID: mdl-28159572
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tubulin / Bridged-Ring Compounds / Xenograft Model Antitumor Assays / Taxoids / Enzyme Inhibitors / Fatty Acid Synthase, Type I / Microtubules Language: En Journal: EBioMedicine Year: 2017 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tubulin / Bridged-Ring Compounds / Xenograft Model Antitumor Assays / Taxoids / Enzyme Inhibitors / Fatty Acid Synthase, Type I / Microtubules Language: En Journal: EBioMedicine Year: 2017 Document type: Article Country of publication: