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Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release.
Xin, Guang; Wei, Zeliang; Ji, Chengjie; Zheng, Huajie; Gu, Jun; Ma, Limei; Huang, Wenfang; Morris-Natschke, Susan L; Yeh, Jwu-Lai; Zhang, Rui; Qin, Chaoyi; Wen, Li; Xing, Zhihua; Cao, Yu; Xia, Qing; Li, Ke; Niu, Hai; Lee, Kuo-Hsiung; Huang, Wen.
Affiliation
  • Xin G; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Natural Products Research Laboratories, UN
  • Wei Z; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Ji C; Clinical Laboratory, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
  • Zheng H; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Integrated Traditional Chine
  • Gu J; Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Ma L; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Huang W; Clinical Laboratory, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
  • Morris-Natschke SL; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
  • Yeh JL; Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Zhang R; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Qin C; Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Wen L; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Integrated Traditional Chine
  • Xing Z; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Cao Y; Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Xia Q; Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.
  • Li K; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Niu H; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; College of Mathematics, Sichuan University
  • Lee KH; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan. Electronic address: khlee@unc.edu.
  • Huang W; Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, the State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: huangwen@scu.edu.cn.
Free Radic Biol Med ; 108: 247-257, 2017 07.
Article in En | MEDLINE | ID: mdl-28188927
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propiophenones / Thrombosis / Flavonoids / Dendritic Cells / Platelet Aggregation Inhibitors / Carotid Arteries / Fibrinolytic Agents / Antioxidants Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2017 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propiophenones / Thrombosis / Flavonoids / Dendritic Cells / Platelet Aggregation Inhibitors / Carotid Arteries / Fibrinolytic Agents / Antioxidants Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2017 Document type: Article Country of publication: