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Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells.
Compagno, Mara; Wang, Qi; Pighi, Chiara; Cheong, Taek-Chin; Meng, Fei-Long; Poggio, Teresa; Yeap, Leng-Siew; Karaca, Elif; Blasco, Rafael B; Langellotto, Fernanda; Ambrogio, Chiara; Voena, Claudia; Wiestner, Adrian; Kasar, Siddha N; Brown, Jennifer R; Sun, Jing; Wu, Catherine J; Gostissa, Monica; Alt, Frederick W; Chiarle, Roberto.
Affiliation
  • Compagno M; Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Wang Q; Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Pighi C; Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Cheong TC; Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Meng FL; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Poggio T; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino 10126, Italy.
  • Yeap LS; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Karaca E; Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Blasco RB; Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Langellotto F; Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Ambrogio C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Voena C; Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Wiestner A; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino 10126, Italy.
  • Kasar SN; Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
  • Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Sun J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Gostissa M; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Chiarle R; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature ; 542(7642): 489-493, 2017 02 23.
Article in En | MEDLINE | ID: mdl-28199309

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Genomic Instability / Class I Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors Language: En Journal: Nature Year: 2017 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Genomic Instability / Class I Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors Language: En Journal: Nature Year: 2017 Document type: Article Affiliation country: