Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist?
Arch Endocrinol Metab
; 61(3): 276-281, 2017.
Article
in En
| MEDLINE
| ID: mdl-28225987
ABSTRACT
OBJECTIVE:
The objective of this study is to evaluate the performance of mathematical models used in non-invasive diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients to determine when the patient needs to be referred to a hepatologist. SUBJECTS ANDMETHODS:
Patients referred by endocrinologists to the liver outpatient departments in two hospitals in Curitiba, Brazil, over a 72-month period were analyzed. The results calculated using the APRI, FIB 4, FORNS and NAFLD Fibrosis Score non-invasive liver fibrosis assessment models were analyzed and compared with histological staging of this population.RESULTS:
Sixty-seven patients with NAFLD were analyzed. Forty-two of them (62.68%) were female, mean age was 54.76 (±9.63) years, mean body mass index 31.42 (±5.64) and 59 (88.05%) of the 67 cases had glucose intolerance or diabetes. A diagnosis of steatohepatitis was made in 45 (76.27%) of the 59 biopsied patients, and advanced liver fibrosis (stages 3 and 4) was diagnosed in 18 (26.86%) of the 67 patients in the study population. The FIB 4 and NAFLD Fibrosis Score models had a high negative predictive value (93.48% and 93.61%, respectively) in patients with severe liver fibrosis (stages 3 and 4).CONCLUSION:
In conclusion, use of the FIB 4 and NAFLD Fibrosis Score models in NAFLD patients allows a diagnosis of severe liver disease to be excluded.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Referral and Consultation
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Non-alcoholic Fatty Liver Disease
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Endocrinologists
/
Gastroenterologists
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Liver Cirrhosis
Type of study:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Aspects:
Patient_preference
Limits:
Female
/
Humans
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Male
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Middle aged
Language:
En
Journal:
Arch Endocrinol Metab
Year:
2017
Document type:
Article
Affiliation country: