Proteome-Scale Human Interactomics.
Trends Biochem Sci
; 42(5): 342-354, 2017 05.
Article
in En
| MEDLINE
| ID: mdl-28284537
ABSTRACT
Cellular functions are mediated by complex interactome networks of physical, biochemical, and functional interactions between DNA sequences, RNA molecules, proteins, lipids, and small metabolites. A thorough understanding of cellular organization requires accurate and relatively complete models of interactome networks at proteome scale. The recent publication of four human protein-protein interaction (PPI) maps represents a technological breakthrough and an unprecedented resource for the scientific community, heralding a new era of proteome-scale human interactomics. Our knowledge gained from these and complementary studies provides fresh insights into the opportunities and challenges when analyzing systematically generated interactome data, defines a clear roadmap towards the generation of a first reference interactome, and reveals new perspectives on the organization of cellular life.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteins
/
Proteome
/
Protein Interaction Mapping
/
Protein Interaction Maps
Limits:
Humans
Language:
En
Journal:
Trends Biochem Sci
Year:
2017
Document type:
Article