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Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.
Scherer, Daniel; Schworm, Benedikt; Seyler, Claudia; Xynogalos, Panagiotis; Scholz, Eberhard P; Thomas, Dierk; Katus, Hugo A; Zitron, Edgar.
Affiliation
  • Scherer D; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D-69120, Heidelberg, Germany. daniel.scherer@med.uni-heidelberg.de.
  • Schworm B; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D-69120, Heidelberg, Germany.
  • Seyler C; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D-69120, Heidelberg, Germany.
  • Xynogalos P; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
  • Scholz EP; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D-69120, Heidelberg, Germany.
  • Thomas D; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D-69120, Heidelberg, Germany.
  • Katus HA; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D-69120, Heidelberg, Germany.
  • Zitron E; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Naunyn Schmiedebergs Arch Pharmacol ; 390(7): 701-710, 2017 Jul.
Article in En | MEDLINE | ID: mdl-28365825
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 4,5-Diphosphate / Potassium Channels, Inwardly Rectifying / Xanthones / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2017 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 4,5-Diphosphate / Potassium Channels, Inwardly Rectifying / Xanthones / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2017 Document type: Article Affiliation country: Country of publication: