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New Cytotoxic Alkylated Chalcones from Fatoua villosa.
Su, Shi-Yun; Xue, Jing-Jing; Yang, Guang-Yu; Lei, Chun; Hou, Ai-Jun.
Affiliation
  • Su SY; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
  • Xue JJ; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
  • Yang GY; Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., Kunming, 650231, P. R. China.
  • Lei C; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
  • Hou AJ; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
Chem Biodivers ; 14(6)2017 Jun.
Article in En | MEDLINE | ID: mdl-28371315
Three new alkylated chalcones, villosins A - C (1 - 3), five known analogues, together with ten known coumarins, were isolated from Fatoua villosa. The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D-, 2D-NMR, and MS data. Compounds 1 - 3 showed cytotoxicity against five kinds of human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) with IC50 values ranging from 1.4 ± 0.1 to 5.7 ± 0.3 µm.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coumarins / Digitaria / Chalcones / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coumarins / Digitaria / Chalcones / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Country of publication: