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Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.
Hinrichs, Mary Jane Masson; Ryan, Pauline M; Zheng, Bo; Afif-Rider, Shameen; Yu, Xiang Qing; Gunsior, Michele; Zhong, Haihong; Harper, Jay; Bezabeh, Binyam; Vashisht, Kapil; Rebelatto, Marlon; Reed, Molly; Ryan, Patricia C; Breen, Shannon; Patel, Neki; Chen, Cui; Masterson, Luke; Tiberghien, Arnaud; Howard, Phillip W; Dimasi, Nazzareno; Dixit, Rakesh.
Affiliation
  • Hinrichs MJM; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland. hinrichsm@medimmune.com.
  • Ryan PM; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
  • Zheng B; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland.
  • Afif-Rider S; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
  • Yu XQ; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland.
  • Gunsior M; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland.
  • Zhong H; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Harper J; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Bezabeh B; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland.
  • Vashisht K; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
  • Rebelatto M; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
  • Reed M; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
  • Ryan PC; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
  • Breen S; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Patel N; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom.
  • Chen C; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Masterson L; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom.
  • Tiberghien A; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom.
  • Howard PW; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom.
  • Dimasi N; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland.
  • Dixit R; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
Clin Cancer Res ; 23(19): 5858-5868, 2017 Oct 01.
Article in En | MEDLINE | ID: mdl-28630216
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Pyrroles / Benzodiazepines / Breast Neoplasms / Immunoconjugates Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2017 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Pyrroles / Benzodiazepines / Breast Neoplasms / Immunoconjugates Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2017 Document type: Article