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Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly.
Iversen, Ane B; Horsman, Michael R; Jakobsen, Steen; Jensen, Jonas B; Garm, Christian; Jessen, Niels; Breining, Peter; Frøkiær, Jørgen; Busk, Morten.
Affiliation
  • Iversen AB; Department of Experimental Clinical Oncology, Noerrebrogade 44, Bldg. 5, Aarhus University Hospital, Aarhus, Denmark. ane.bundsbaek.iversen@oncology.au.dk.
  • Horsman MR; Department of Experimental Clinical Oncology, Noerrebrogade 44, Bldg. 5, Aarhus University Hospital, Aarhus, Denmark.
  • Jakobsen S; PET Centre, Noerrebrogade 44, Bldg. 10, Aarhus University Hospital, Aarhus, Denmark.
  • Jensen JB; PET Centre, Noerrebrogade 44, Bldg. 10, Aarhus University Hospital, Aarhus, Denmark.
  • Garm C; Biochemical Pathology, Noerrebrogade 44, Aarhus University Hospital, Aarhus, Denmark.
  • Jessen N; Institute for Molecular Biology and Genetics, Ole Worms Allé 3, Bldg. 1170, Aarhus University, Aarhus, Denmark.
  • Breining P; Biochemical Pathology, Noerrebrogade 44, Aarhus University Hospital, Aarhus, Denmark.
  • Frøkiær J; Department of Endocrinology and Metabolism, Noerrebrogade 44, Aarhus University Hospital, Aarhus, Denmark.
  • Busk M; PET Centre, Noerrebrogade 44, Bldg. 10, Aarhus University Hospital, Aarhus, Denmark.
Sci Rep ; 7(1): 9436, 2017 08 25.
Article in En | MEDLINE | ID: mdl-28842630
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon Radioisotopes / Positron-Emission Tomography / Metformin / Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon Radioisotopes / Positron-Emission Tomography / Metformin / Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: Country of publication: