New therapeutic perspectives in non-alcoholic steatohepatitis. / Nuevas perspectivas terapéuticas en la esteatohepatitis no alcohólica.
Gastroenterol Hepatol
; 41(2): 128-142, 2018 Feb.
Article
in En, Es
| MEDLINE
| ID: mdl-28874313
ABSTRACT
Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able to improve steatosis, ballooning and fibrosis. Life-style interventions based on Mediterranean diet and increasing physical activity are the first line therapy. In patients with unsuccessful life-style intervention several drugs are under development agonist PPAR, agonist GLP-1R and agonist FXR together with drugs focussing on inflammation, ballooning, apoptosis and fibrosis. Bariatric surgery or advanced endoscopy are reserved for morbid obese without response to life-style intervention and weighting loss drugs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Non-alcoholic Fatty Liver Disease
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
/
Es
Journal:
Gastroenterol Hepatol
Year:
2018
Document type:
Article