[Adenosine - a mediator with multisystemic effects (or a hormone?)]. / Adenozín - mediátor s multisystémovými úcinkami (alebo hormón?).
Vnitr Lek
; 63(9): 617-623, 2017.
Article
in Cs
| MEDLINE
| ID: mdl-29120660
ABSTRACT
Adenosine is a nucleoside regulating many physiological and pathological processes in human organism. It is produced by almost all cells and is metabolised by adenosinedeaminase enzyme. Effect of adenosine is mediated by three types of adenosine receptors. Adenosinergic system significantly influences function of cardiovascular system, furthemore it plays a key role in sleep homeostasis, in regulation of bone metabolism and activation of immune system. Adenosine mediates effect of various hormones, but also adenosine itself has its own autocrine, paracrine and systemic effects. Changes in endogenous adenosine levels, or changes of adenosine receptor sensitivity, may play a role in ethiopathogenesis of many diseases. Thus adenosinergic system can become a target for new therapeutical possibilities in many fields of medicine.Key words adenosine - adenosinedeaminase - cardiovascular system - diabetes mellitus - hormone.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenosine
Limits:
Animals
/
Humans
Language:
Cs
Journal:
Vnitr Lek
Year:
2017
Document type:
Article