Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critically [corrected] ill patients?
Ann Intensive Care
; 7(1): 115, 2017 12 01.
Article
in En
| MEDLINE
| ID: mdl-29192366
ABSTRACT
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Ann Intensive Care
Year:
2017
Document type:
Article
Affiliation country: