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Ultrasensitive Electroanalysis: Femtomolar Determination of Lead, Cobalt, and Nickel.
Zhou, Min; Dick, Jeffrey E; Hu, Keke; Mirkin, Michael V; Bard, Allen J.
Affiliation
  • Zhou M; Center for Electrochemistry, Department of Chemistry, The University of Texas at Austin , Austin, Texas 78712, United States.
  • Dick JE; Center for Electrochemistry, Department of Chemistry, The University of Texas at Austin , Austin, Texas 78712, United States.
  • Hu K; Department of Chemistry and Biochemistry, Queens College, City University of New York , Flushing, New York 11367, United States.
  • Mirkin MV; Department of Chemistry and Biochemistry, Queens College, City University of New York , Flushing, New York 11367, United States.
  • Bard AJ; Center for Electrochemistry, Department of Chemistry, The University of Texas at Austin , Austin, Texas 78712, United States.
Anal Chem ; 90(2): 1142-1146, 2018 01 16.
Article in En | MEDLINE | ID: mdl-29215262
We demonstrate the feasibility of attaining femtomolar limits of quantitation in electroanalysis. The method employed is based on electrocatalytic amplification, where small quantities of metal deposit performed on a carbon electrode causes a large increase in the observed current, for example, for the oxidation of water. We show calibration curves at the femtomolar level for cobalt, nickel, and lead ions on carbon ultramicroelectrodes (CUMEs), ca. 500 nm radii. The CUME was biased at a potential where the ion would deposit as the metal oxide, MOx, and a high concentration of species that is oxidized at the deposit is present in solution. Blips were observed in the amperometric i-t response, and their frequency scaled linearly with the concentration of ions at the femtomolar level. From these results, the limits of quantitation for cobalt, nickel, and lead ions were reported at 10 s of femtomolar level for the first time.

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Anal Chem Year: 2018 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Anal Chem Year: 2018 Document type: Article Affiliation country: Country of publication: