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Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.
Shen, Ying-Qiang; Guerra-Librero, Ana; Fernandez-Gil, Beatriz I; Florido, Javier; García-López, Sergio; Martinez-Ruiz, Laura; Mendivil-Perez, Miguel; Soto-Mercado, Viviana; Acuña-Castroviejo, Darío; Ortega-Arellano, Hector; Carriel, Victor; Diaz-Casado, María E; Reiter, Russel J; Rusanova, Iryna; Nieto, Ana; López, Luis C; Escames, Germaine.
Affiliation
  • Shen YQ; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • Guerra-Librero A; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • Fernandez-Gil BI; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • Florido J; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • García-López S; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • Martinez-Ruiz L; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • Mendivil-Perez M; Medical Research Institute, Faculty of Medicine, University of Antioquia, Medellin, Colombia.
  • Soto-Mercado V; Medical Research Institute, Faculty of Medicine, University of Antioquia, Medellin, Colombia.
  • Acuña-Castroviejo D; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • Ortega-Arellano H; Department of Physiology, Faculty of Medicine, University of Granada, Granada, Spain.
  • Carriel V; CIBERFES, Ibs.Granada, Hospital Campus de la Salud, Granada, Spain.
  • Diaz-Casado ME; Medical Research Institute, Faculty of Medicine, University of Antioquia, Medellin, Colombia.
  • Reiter RJ; Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain.
  • Rusanova I; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • Nieto A; Department of Cell Systems and Anatomy, UT Health, San Antonio, TX, USA.
  • López LC; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Granada, Spain.
  • Escames G; CIBERFES, Ibs.Granada, Hospital Campus de la Salud, Granada, Spain.
J Pineal Res ; 64(3)2018 Apr.
Article in En | MEDLINE | ID: mdl-29247557
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Signal Transduction / Antineoplastic Combined Chemotherapy Protocols / Apoptosis / Mitophagy / Head and Neck Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Pineal Res Journal subject: ENDOCRINOLOGIA Year: 2018 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Signal Transduction / Antineoplastic Combined Chemotherapy Protocols / Apoptosis / Mitophagy / Head and Neck Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Pineal Res Journal subject: ENDOCRINOLOGIA Year: 2018 Document type: Article Affiliation country: Country of publication: