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[Experience with cabazitaxel therapy for patients with metastatic castrate resistant prostate cancer in Hungary]. / Hazai tapasztalatok kasztrációrezisztens metasztatikus prosztatadaganatos betegek kabazitaxelterápiájával.
Maráz, Anikó; Boér, Katalin; Dankovics, Zsófia; Dank, Magdolna; Lahm, Erika; Petrányi, Ágota; Révész, János; Ruzsa, Ágnes; Szûcs, Miklós; Valikovics, Anikó; Vas, Mária; Küronya, Zsófia.
Affiliation
  • Maráz A; Onkoterápiás Klinika, Szegedi Tudományegyetem, Szeged, Hungary. dr.aniko.maraz@gmail.com.
  • Boér K; Onkológia, Szent Margit Kórház, Budapest, Hungary.
  • Dankovics Z; Onkoradiológiai Osztály, Markusovszky Egyetemi Oktató Kórház, Szombathely, Hungary.
  • Dank M; Onkológiai Központ, Semmelweis Egyetem, Budapest, Hungary.
  • Lahm E; Onkológiai Osztály, Magyar Honvédség Egészségügyi Központ, Budapest, Hungary.
  • Petrányi Á; Onkológiai Osztály, Egyesített Szent István és Szent László Kórház, Budapest, Hungary.
  • Révész J; Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház, Miskolc, Hungary.
  • Ruzsa Á; Klinikai Onkológiai Centrum, Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár, Hungary.
  • Szûcs M; Urológiai Klinika, Semmelweis Egyetem, Uroonkológiai Központ, Budapest, Hungary.
  • Valikovics A; Fõvárosi Onkoradiológiai Központ, Uzsoki Utcai Oktató Kórház, Budapest, Hungary.
  • Vas M; Onkológia-Hematológia Osztály, Péterfy Sándor Utcai Kórház, Budapest, Hungary.
  • Küronya Z; C Belgyógyászati-Onkológiai és Klinikai Farmakológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary.
Magy Onkol ; 61(4): 353-360, 2017 Dec 18.
Article in Hu | MEDLINE | ID: mdl-29257155
Our aim was to assess the efficacy and adverse effects of cabazitaxel (CBZ), a chemotherapeutic agent that can be administered to patients with metastatic castrate resistant prostate cancer (mCRPC) after docetaxel (DOC) therapy. We retrospectively analyzed data of CBZ received by mCRPC patients in 12 Hungarian oncological centers between 01/2016 and 06/2017. CBZ (25 or 20 mg/m2 q3w) was administered after DOC. Physical and laboratory examinations were performed in every cycle, tumor response was evaluated in every third cycle based on PCWG2 criteria. Adverse effects were evaluated based on CTCAE 4.0. Data of 60 patients were analyzed. CBZ was administered in 2nd and 3rd lines in 31.6% and 46.6%, while in 4th and 5th lines in 15% and 6.6% patients, respectively. Its starting dose was 25 mg/m2 and 20 mg/m2 in 65% and 35% of cases, respectively. The median number of cycles was 5. Progression-free survival and overall survival were 5.52 and 15.77 months, respectively. Survival results were similar in case of DOC-CBZ-ART/alfaradin and DOC-ART/alfaradin-CBZ sequences. Adverse effects were detected in 63,3% of patients. The most common adverse effects were neutropenia, anemia, and diarrhea. Our observations suggest that CBZ, with the appropriate support and chemotherapeutic experience, is well-tolerated and effective therapy of mCRPC after DOC.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Prostate-Specific Antigen / Taxoids / Prostatic Neoplasms, Castration-Resistant Type of study: Etiology_studies / Evaluation_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Humans / Male / Middle aged Country/Region as subject: Europa Language: Hu Journal: Magy Onkol Journal subject: NEOPLASIAS Year: 2017 Document type: Article Affiliation country: Country of publication:
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Collection: 01-internacional Database: MEDLINE Main subject: Prostate-Specific Antigen / Taxoids / Prostatic Neoplasms, Castration-Resistant Type of study: Etiology_studies / Evaluation_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Humans / Male / Middle aged Country/Region as subject: Europa Language: Hu Journal: Magy Onkol Journal subject: NEOPLASIAS Year: 2017 Document type: Article Affiliation country: Country of publication: