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Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition.
Dey, Joyoti; Deckwerth, Thomas L; Kerwin, William S; Casalini, Joseph R; Merrell, Angela J; Grenley, Marc O; Burns, Connor; Ditzler, Sally H; Dixon, Chantel P; Beirne, Emily; Gillespie, Kate C; Kleinman, Edward F; Klinghoffer, Richard A.
Affiliation
  • Dey J; Presage Biosciences, Inc, Seattle, WA, USA.
  • Deckwerth TL; Presage Biosciences, Inc, Seattle, WA, USA.
  • Kerwin WS; Presage Biosciences, Inc, Seattle, WA, USA.
  • Casalini JR; Presage Biosciences, Inc, Seattle, WA, USA.
  • Merrell AJ; Presage Biosciences, Inc, Seattle, WA, USA.
  • Grenley MO; Presage Biosciences, Inc, Seattle, WA, USA.
  • Burns C; Presage Biosciences, Inc, Seattle, WA, USA.
  • Ditzler SH; Presage Biosciences, Inc, Seattle, WA, USA.
  • Dixon CP; Presage Biosciences, Inc, Seattle, WA, USA.
  • Beirne E; Presage Biosciences, Inc, Seattle, WA, USA.
  • Gillespie KC; Presage Biosciences, Inc, Seattle, WA, USA.
  • Kleinman EF; Edward F. Kleinman LLC, Pawcatuck, CT, USA.
  • Klinghoffer RA; Presage Biosciences, Inc, Seattle, WA, USA. rich.klinghoffer@presagebio.com.
Sci Rep ; 7(1): 18007, 2017 12 21.
Article in En | MEDLINE | ID: mdl-29269870
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzopyrans / Gene Expression Regulation / Lymphoma, Large B-Cell, Diffuse / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Imino Furanoses / Myeloid Cell Leukemia Sequence 1 Protein / Antineoplastic Agents Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzopyrans / Gene Expression Regulation / Lymphoma, Large B-Cell, Diffuse / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Imino Furanoses / Myeloid Cell Leukemia Sequence 1 Protein / Antineoplastic Agents Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: