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Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.
Willems, Sara M; Wright, Daniel J; Day, Felix R; Trajanoska, Katerina; Joshi, Peter K; Morris, John A; Matteini, Amy M; Garton, Fleur C; Grarup, Niels; Oskolkov, Nikolay; Thalamuthu, Anbupalam; Mangino, Massimo; Liu, Jun; Demirkan, Ayse; Lek, Monkol; Xu, Liwen; Wang, Guan; Oldmeadow, Christopher; Gaulton, Kyle J; Lotta, Luca A; Miyamoto-Mikami, Eri; Rivas, Manuel A; White, Tom; Loh, Po-Ru; Aadahl, Mette; Amin, Najaf; Attia, John R; Austin, Krista; Benyamin, Beben; Brage, Søren; Cheng, Yu-Ching; Cieszczyk, Pawel; Derave, Wim; Eriksson, Karl-Fredrik; Eynon, Nir; Linneberg, Allan; Lucia, Alejandro; Massidda, Myosotis; Mitchell, Braxton D; Miyachi, Motohiko; Murakami, Haruka; Padmanabhan, Sandosh; Pandey, Ashutosh; Papadimitriou, Ioannis; Rajpal, Deepak K; Sale, Craig; Schnurr, Theresia M; Sessa, Francesco; Shrine, Nick; Tobin, Martin D.
Affiliation
  • Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
  • Wright DJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
  • Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
  • Trajanoska K; Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Joshi PK; Department of Epidemiology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Morris JA; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK.
  • Matteini AM; Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada QC H3T 1E2.
  • Garton FC; Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3G 0B1.
  • Grarup N; Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
  • Oskolkov N; Queensland Brain Institute, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Thalamuthu A; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  • Mangino M; Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skånes University Hospital, 222 41 Lund, Sweden.
  • Liu J; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2031, Australia.
  • Demirkan A; Department of Twin Research &Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
  • Lek M; NIHR Biomedical Research Centre at Guy's and St. Thomas' NHS Foundation Trust, London SE1 9RT, UK.
  • Xu L; Department of Epidemiology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Wang G; Department of Epidemiology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Oldmeadow C; Department of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Gaulton KJ; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Maryland 02114, USA.
  • Lotta LA; Harvard Medical School, Boston, Maryland 02115, USA.
  • Miyamoto-Mikami E; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Maryland 02114, USA.
  • Rivas MA; Harvard Medical School, Boston, Maryland 02115, USA.
  • White T; Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton, Eastbourne BN20 7SN, UK.
  • Loh PR; Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia.
  • Aadahl M; Department of Pediatrics, University of California San Diego, La Jolla, California 92093, USA.
  • Amin N; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
  • Attia JR; Japan Society for the Promotion of Science, Tokyo 102-0083, Japan.
  • Austin K; Department of Sports and Life Science, National Institute of Fitness and Sports, Kanoya, Kagoshima 891-2393, Japan.
  • Benyamin B; Department of Biomedical Data Sciences, Stanford University, Stanford, California 94305, USA.
  • Brage S; BROAD Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
  • Cheng YC; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
  • Cieszczyk P; BROAD Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
  • Derave W; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
  • Eriksson KF; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, DK-2600 Glostrup, Denmark.
  • Eynon N; Department of Epidemiology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Linneberg A; Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia.
  • Lucia A; Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales 2308, Australia.
  • Massidda M; John Hunter Hospital, New Lambton, New South Wales 2305, Australia.
  • Mitchell BD; Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton, Eastbourne BN20 7SN, UK.
  • Miyachi M; Queensland Brain Institute, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Murakami H; Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Padmanabhan S; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
  • Pandey A; Division of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
  • Papadimitriou I; Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland.
  • Rajpal DK; Department of Movement and Sports Sciences, Ghent University, 9000 Ghent, Belgium.
  • Sale C; Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skånes University Hospital, 222 41 Lund, Sweden.
  • Schnurr TM; Institute of Sport, Exercise &Active Living (ISEAL), Victoria University, Melbourne, Victoria 8001, Australia.
  • Sessa F; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.
  • Shrine N; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, DK-2600 Glostrup, Denmark.
  • Tobin MD; Department of Clinical Experimental Research, Rigshospitalet, 2600 Glostrup, Denmark.
Nat Commun ; 8: 16015, 2017 07 12.
Article in En | MEDLINE | ID: mdl-29313844
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hand Strength / Genome-Wide Association Study / Genetics, Population / Hand Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hand Strength / Genome-Wide Association Study / Genetics, Population / Hand Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: Country of publication: