Determination of the Lung Clearance Index (LCI) in a Paediatric Cystic Fibrosis Cohort.
Ir Med J
; 110(9): 629, 2017 Oct 10.
Article
in En
| MEDLINE
| ID: mdl-29372944
ABSTRACT
The pathogenesis of CF lung disease may start in infancy. Therefore, it is important to monitor the early stages of its progress. The Exhalyzer D is the first commercially available device designed to measure lung ventilation inhomogeneity at any age. This study was conducted to assess the performance and feasibility of using the Exhalyzer D in a paediatric CF clinic. A total of 91 subjects were recruited (23 controls, and 68 patients with CF). The majority of CF patients (79%) and controls (78%) completed at least two successful washouts. A strong linear correlation was noted between LCI and FEV1. Children with CF under six years of age struggled to perform the washout in a technically correct manner. A clear learning effect was observed, with improved technique and shorter testing times on repeated visits.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pulmonary Ventilation
/
Cystic Fibrosis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Language:
En
Journal:
Ir Med J
Year:
2017
Document type:
Article
Affiliation country: