[Circulation and etiological characterization of Salmonella enterica serotype in human in Guangdong province, 2007-2016].
Zhonghua Liu Xing Bing Xue Za Zhi
; 39(1): 63-66, 2018 Jan 10.
Article
in Zh
| MEDLINE
| ID: mdl-29374898
ABSTRACT
Objective:
To understand the circulation, drug resistance and molecular characteristics of Salmonella1, 4, [5], 12 i- in human in Guangdong province.Methods:
Salmonella1, 4, [5], 12 i- isolated from diarrhea patients in Guangdong during 2007-2016 were detected for drug resistance, genes and PFGE characteristics.Results:
A total of 2 960 strains Salmonella1, 4, [5], 12 i - were isolated from human diarrhea cases during this period. The positive rates of the isolation increased year by year. The male to female ratio of the infection cases was 1.58â¶1, and the infection mainly occurred in infants and young children. Except imipenem, Salmonella1, 4, [5], 12 i - was resistant to other 17 antibiotics to some extent. The drug resistant rates to ceftazidime, cefotaxime and ciprofloxacin increased from 2011 to 2016. Multi-drug resistance was serious, for example, the multi-drug resistant strains with ASSuT accounted for 70.62% (435/616) and the multi-drug resistant strains with ACSuGSTTm accounted for 27.11% (167/616). The lack of fljA, fljB and hin genes, as well as the retaining of iroB, STM2740, STM2757 genes, resulted in the unable expression of FljBenx gene with 8 different defection profiles. There were 934 different PFGE patterns observed in 2 347 strains, which displayed a relatively large fingerprint polymorphism. The major PFGE pattern was JPXX01. GD0226, which was found in 97 strains, accounting for 4.13% (97/2 347). The PFGE patterns in 168 Salmonella1, 4, [5], 12 i - strains were consistent with that of Salmonella typhimurium.Conclusions:
Salmonella1,4,[5], 12 i - strains has become the major serotype of Salmonella that cause diarrhea in human in Guangdong. The multi-drug resistance of Salmonella1,4, [5], 12 i - was serious, and since the defection of fljA, fljB and hin genes, the expression of FljBenx protein failed. The PFGE results were diverse, which displayed polymorphism in inheritance.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salmonella Infections
/
Salmonella enterica
/
Diarrhea
/
Anti-Bacterial Agents
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Zhonghua Liu Xing Bing Xue Za Zhi
Year:
2018
Document type:
Article
Affiliation country: