Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy.
Chem Commun (Camb)
; 54(16): 1996-1999, 2018 Feb 20.
Article
in En
| MEDLINE
| ID: mdl-29411840
ABSTRACT
We report that carbonate esters could turn hydrophobic camptothecin (CPT)-unsaturated fatty acid prodrugs into nanoaggregates in aqueous solution. The active CPT could be rapidly released once triggered by a reductive stimulus when a carbonate ester was combined with a disulfide bond, resulting in a potent in vivo antitumor activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Camptothecin
/
Carbonates
/
Prodrugs
/
Esters
/
Nanomedicine
/
Fatty Acids, Unsaturated
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2018
Document type:
Article
Affiliation country: