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Targeting the bone marrow microenvironment in acute leukemia.
Karantanou, Christina; Godavarthy, Parimala Sonika; Krause, Daniela S.
Affiliation
  • Karantanou C; a Institute for Tumor Biology and Experimental Therapy , Georg-Speyer-Haus , Frankfurt am Main , Germany.
  • Godavarthy PS; a Institute for Tumor Biology and Experimental Therapy , Georg-Speyer-Haus , Frankfurt am Main , Germany.
  • Krause DS; a Institute for Tumor Biology and Experimental Therapy , Georg-Speyer-Haus , Frankfurt am Main , Germany.
Leuk Lymphoma ; 59(11): 2535-2545, 2018 11.
Article in En | MEDLINE | ID: mdl-29431560
Despite individual differences between certain leukemias, the overall survival rate in acute leukemia remains low at approximately 40%. Novel therapeutics, including targeted therapies like tyrosine kinase inhibitors, have been incorporated into treatment regimens, but most have failed at eradicating leukemic stem cells (LSCs). The causes of disease relapse, progression, and resistance to chemotherapy are as yet not entirely clear but thought to be linked to protection in the bone marrow microenvironment (BMM). In this review, we summarize current knowledge on the BMM in acute leukemias and examine the ongoing efforts to target the BMM, which include treatment strategies targeting (a) leukemia-BMM interactions, (b) leukemia-cell intrinsic pathways influenced by the BMM, and (c) direct BMM targeting strategies. It is likely that the future ploy against leukemia will involve these and other innovative strategies designed to eradicate the last remaining warrior - the LSC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Bone Marrow / Leukemia, Myeloid, Acute / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Stem Cell Niche / Tumor Microenvironment / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2018 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Bone Marrow / Leukemia, Myeloid, Acute / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Stem Cell Niche / Tumor Microenvironment / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2018 Document type: Article Affiliation country: Country of publication: