Dengue seroprevalence: data from the clinical development of a tetravalent dengue vaccine in 14 countries (2005-2014).
Trans R Soc Trop Med Hyg
; 112(4): 158-168, 2018 04 01.
Article
in En
| MEDLINE
| ID: mdl-29800279
ABSTRACT
Dengue seroprevalence data in the literature is limited and the available information is difficult to compare between studies because of the varying survey designs and methods used. We assessed dengue seropositivity across 14 countries using data from 15 trials conducted during the development of a tetravalent dengue vaccine between October 2005 and February 2014. Participants' dengue seropositivity (n=8592) was determined from baseline (before vaccination) serum samples at two centralized laboratories with the plaque reduction neutralization test (PRNT50). Seropositivity rates generally increased with age in endemic settings. Although seropositivity rates varied across geographical areas, between countries, and within countries by region, no major differences were observed for given age groups between the two endemic regions, Latin America and Asia-Pacific. Seropositivity rates were generally stable over time. The proportion of participants who had only experienced primary infection tended to be higher in younger children than adolescents/adults. These results will help inform and guide dengue control strategies in the participating countries.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vaccines, Attenuated
/
Dengue
/
Dengue Vaccines
/
Immunogenicity, Vaccine
Type of study:
Qualitative_research
Limits:
Animals
/
Humans
Language:
En
Journal:
Trans R Soc Trop Med Hyg
Year:
2018
Document type:
Article