The Role of the Programmed Death Receptor-1/Programmed Death Ligand-1: Immunologic Checkpoint in Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma.
Arch Pathol Lab Med
; 142(6): 719-720, 2018 06.
Article
in En
| MEDLINE
| ID: mdl-29848031
ABSTRACT
CONTEXT - There has been increasing interest in understanding the role of programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) pathway in cancer biology and its clinical significance in cancer therapy. OBJECTIVE:
- To discuss the studies of the PD-1/PD-L1 pathway in human papillomavirus-positive head and neck squamous cell carcinoma, focusing on the pathogenesis of cancer, characterization of the tumor microenvironment, and the effect of such studies in laboratory medicine. DATA SOURCES - Data sources included peer-reviewed literature and reputable online sources.CONCLUSIONS:
- To date, there are few studies of PD-1 and PD-L1 in human papillomavirus-positive head and neck squamous cell carcinoma. There is evidence that the PD-1/PD-L1 pathway has a role in this type of cancer; however, further studies are needed to better characterize the effect of the human papillomavirus and its use as a marker of therapy response.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Papillomaviridae
/
Papillomavirus Infections
/
B7-H1 Antigen
/
Programmed Cell Death 1 Receptor
/
Squamous Cell Carcinoma of Head and Neck
/
Head and Neck Neoplasms
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Arch Pathol Lab Med
Year:
2018
Document type:
Article