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Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development.
Liu, Zhidong; Zhang, Zhuangzhi; Lindtner, Susan; Li, Zhenmeiyu; Xu, Zhejun; Wei, Song; Liang, Qifei; Wen, Yan; Tao, Guangxu; You, Yan; Chen, Bin; Wang, Yanling; Rubenstein, John L; Yang, Zhengang.
Affiliation
  • Liu Z; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Zhang Z; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Lindtner S; Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
  • Li Z; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Xu Z; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Wei S; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Liang Q; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Wen Y; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Tao G; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • You Y; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Chen B; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.
  • Wang Y; Department of Neurological Sciences, Rush University Medical Center, Rush University, Chicago, IL, USA.
  • Rubenstein JL; Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
  • Yang Z; State Key Laboratory of Medical Neurobiology, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
Cereb Cortex ; 29(6): 2653-2667, 2019 06 01.
Article in En | MEDLINE | ID: mdl-29878134
ABSTRACT
Immature neurons generated by the subpallial MGE tangentially migrate to the cortex where they become parvalbumin-expressing (PV+) and somatostatin (SST+) interneurons. Here, we show that the Sp9 transcription factor controls the development of MGE-derived cortical interneurons. SP9 is expressed in the MGE subventricular zone and in MGE-derived migrating interneurons. Sp9 null and conditional mutant mice have approximately 50% reduction of MGE-derived cortical interneurons, an ectopic aggregation of MGE-derived neurons in the embryonic ventral telencephalon, and an increased ratio of SST+/PV+ cortical interneurons. RNA-Seq and SP9 ChIP-Seq reveal that SP9 regulates MGE-derived cortical interneuron development through controlling the expression of key transcription factors Arx, Lhx6, Lhx8, Nkx2-1, and Zeb2 involved in interneuron development, as well as genes implicated in regulating interneuron migration Ackr3, Epha3, and St18. Thus, Sp9 has a central transcriptional role in MGE-derived cortical interneuron development.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Cortex / RNA-Binding Proteins / Neurogenesis / Interneurons / Median Eminence Limits: Animals Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2019 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Cortex / RNA-Binding Proteins / Neurogenesis / Interneurons / Median Eminence Limits: Animals Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2019 Document type: Article Affiliation country: