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Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.
Strangward, Patrick; Haley, Michael J; Albornoz, Manuel G; Barrington, Jack; Shaw, Tovah; Dookie, Rebecca; Zeef, Leo; Baker, Syed M; Winter, Emma; Tzeng, Te-Chen; Golenbock, Douglas T; Cruickshank, Sheena M; Allan, Stuart M; Craig, Alister; Liew, Foo Y; Brough, David; Couper, Kevin N.
Affiliation
  • Strangward P; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Haley MJ; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Albornoz MG; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Barrington J; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Shaw T; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Dookie R; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Zeef L; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Baker SM; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Winter E; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Tzeng TC; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Golenbock DT; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Cruickshank SM; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Allan SM; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom.
  • Craig A; Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
  • Liew FY; Department of Immunology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow G12 8TA, United Kingdom.
  • Brough D; School of Biology and Basic Medical Sciences, Soochow University, 215006 Suzhou, China.
  • Couper KN; School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom; david.brough@manchester.ac.uk kevin.couper@manchester.ac.uk.
Proc Natl Acad Sci U S A ; 115(28): 7404-7409, 2018 07 10.
Article in En | MEDLINE | ID: mdl-29954866

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Brain / Malaria, Falciparum / Malaria, Cerebral / Drug Delivery Systems / Interleukin-33 / NLR Family, Pyrin Domain-Containing 3 Protein / Antimalarials Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Brain / Malaria, Falciparum / Malaria, Cerebral / Drug Delivery Systems / Interleukin-33 / NLR Family, Pyrin Domain-Containing 3 Protein / Antimalarials Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Affiliation country: Country of publication: