Genetic and evolutionary determinants of human population variation in immune responses.
Curr Opin Genet Dev
; 53: 28-35, 2018 12.
Article
in En
| MEDLINE
| ID: mdl-29960896
ABSTRACT
Humans display remarkable immune response variation when exposed to identical immune challenges. However, our understanding of the genetic, evolutionary, and environmental factors that impact this inter-individual and inter-population immune response heterogeneity is still in its early days. In this review, we discuss three fundamental questions concerning the recent evolution of the human immune system the degree to which individuals from different populations vary in their innate immune responses, the genetic variants accounting for such differences, and the evolutionary mechanisms that led to the establishment of these variants in modern human populations. We also discuss how past selective events might have contributed to the uneven distribution of immune-related disorders across populations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Evolution, Molecular
/
Genetics, Population
/
Immunity, Innate
Limits:
Humans
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2018
Document type:
Article
Affiliation country: