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The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease.
DeWald, Lisa Evans; Dyall, Julie; Sword, Jennifer M; Torzewski, Lisa; Zhou, Huanying; Postnikova, Elena; Kollins, Erin; Alexander, Isis; Gross, Robin; Cong, Yu; Gerhardt, Dawn M; Johnson, Reed F; Olinger, Gene G; Holbrook, Michael R; Hensley, Lisa E; Jahrling, Peter B.
Affiliation
  • DeWald LE; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Dyall J; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Sword JM; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Torzewski L; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Zhou H; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Postnikova E; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Kollins E; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Alexander I; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Gross R; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Cong Y; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Gerhardt DM; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Johnson RF; Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Olinger GG; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Holbrook MR; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Hensley LE; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
  • Jahrling PB; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland.
J Infect Dis ; 218(suppl_5): S588-S591, 2018 11 22.
Article in En | MEDLINE | ID: mdl-29982632
No therapeutics are approved for the treatment of filovirus infections. Bepridil, a calcium channel blocker developed for treating angina, was identified as a potent inhibitor of filoviruses in vitro, including Ebola and Marburg viruses, and Ebola virus in vivo. We evaluated the efficacy of bepridil in a lethal mouse model of Marburg virus disease. A dose of 12 mg/kg bepridil once or twice daily resulted in 80% or 90% survival, respectively. These data confirm bepridil's broad-spectrum anti-filovirus activity warranting further investigation of bepridil, or improved compounds with a similar mechanism, as a pan-filovirus therapeutic agent.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channel Blockers / Bepridil / Marburg Virus Disease Limits: Animals Language: En Journal: J Infect Dis Year: 2018 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channel Blockers / Bepridil / Marburg Virus Disease Limits: Animals Language: En Journal: J Infect Dis Year: 2018 Document type: Article Country of publication: