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PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling.
Yen, Hsin-Yung; Hoi, Kin Kuan; Liko, Idlir; Hedger, George; Horrell, Michael R; Song, Wanling; Wu, Di; Heine, Philipp; Warne, Tony; Lee, Yang; Carpenter, Byron; Plückthun, Andreas; Tate, Christopher G; Sansom, Mark S P; Robinson, Carol V.
Affiliation
  • Yen HY; Chemical Research Laboratory, University of Oxford, Oxford, UK.
  • Hoi KK; OMass Technologies, Kidlington, UK.
  • Liko I; Chemical Research Laboratory, University of Oxford, Oxford, UK.
  • Hedger G; Chemical Research Laboratory, University of Oxford, Oxford, UK.
  • Horrell MR; OMass Technologies, Kidlington, UK.
  • Song W; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Wu D; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Heine P; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Warne T; Chemical Research Laboratory, University of Oxford, Oxford, UK.
  • Lee Y; Biochemisches Institut, Universität Zürich, Zurich, Switzerland.
  • Carpenter B; MRC Laboratory of Molecular Biology, Cambridge, UK.
  • Plückthun A; MRC Laboratory of Molecular Biology, Cambridge, UK.
  • Tate CG; MRC Laboratory of Molecular Biology, Cambridge, UK.
  • Sansom MSP; Warwick Integrative Synthetic Biology Centre, School of Life Sciences, The University of Warwick, Coventry, UK.
  • Robinson CV; Biochemisches Institut, Universität Zürich, Zurich, Switzerland.
Nature ; 559(7714): 423-427, 2018 07.
Article in En | MEDLINE | ID: mdl-29995853
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 4,5-Diphosphate / Heterotrimeric GTP-Binding Proteins / Receptors, G-Protein-Coupled Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2018 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 4,5-Diphosphate / Heterotrimeric GTP-Binding Proteins / Receptors, G-Protein-Coupled Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2018 Document type: Article Affiliation country: