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Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome.
Surikow, Sven Y; Nguyen, Thanh H; Stafford, Irene; Chapman, Matthew; Chacko, Sujith; Singh, Kuljit; Licari, Giovanni; Raman, Betty; Kelly, Darren J; Zhang, Yuan; Waddingham, Mark T; Ngo, Doan T; Bate, Alexander P; Chua, Su Jen; Frenneaux, Michael P; Horowitz, John D.
Affiliation
  • Surikow SY; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.
  • Nguyen TH; Basil Hetzel Institute, Adelaide, South Australia, Australia.
  • Stafford I; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.
  • Chapman M; Basil Hetzel Institute, Adelaide, South Australia, Australia.
  • Chacko S; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.
  • Singh K; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.
  • Licari G; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.
  • Raman B; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.
  • Kelly DJ; Basil Hetzel Institute, Adelaide, South Australia, Australia.
  • Zhang Y; Basil Hetzel Institute, Adelaide, South Australia, Australia.
  • Waddingham MT; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.
  • Ngo DT; Basil Hetzel Institute, Adelaide, South Australia, Australia.
  • Bate AP; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia.
  • Chua SJ; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia.
  • Frenneaux MP; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia.
  • Horowitz JD; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.
JACC Basic Transl Sci ; 3(2): 213-226, 2018 Apr.
Article in En | MEDLINE | ID: mdl-30062207
Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant ß-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: JACC Basic Transl Sci Year: 2018 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: JACC Basic Transl Sci Year: 2018 Document type: Article Affiliation country: Country of publication: