Autophagy and mitochondrial metabolism: insights into their role and therapeutic potential in chronic myeloid leukaemia.
FEBS J
; 286(7): 1271-1283, 2019 04.
Article
in En
| MEDLINE
| ID: mdl-30222247
ABSTRACT
Despite the development of selective BCR-ABL-targeting tyrosine kinase inhibitors (TKIs) transforming the management of chronic myeloid leukaemia (CML), therapy-resistant leukaemic stem cells (LSCs) persist after TKI treatment and present an obstacle to a CML cure. Recently, we and others have made significant contributions to the field by unravelling survival dependencies in LSCs to work towards the goal of eradicating LSCs in CML patients. In this review, we describe these findings focusing on autophagy and mitochondrial metabolism, which have recently been uncovered as two essential processes for LSCs quiescence and survival respectively. In addition, we discuss the therapeutic potential of autophagy and mitochondrial metabolism inhibition as a strategy to eliminate CML cells in patients where the resistance to TKI is driven by BCR-ABL-independent mechanism(s).
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Neoplastic Stem Cells
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Drug Resistance, Neoplasm
/
Protein Kinase Inhibitors
/
Mitochondria
Limits:
Animals
/
Humans
Language:
En
Journal:
FEBS J
Journal subject:
BIOQUIMICA
Year:
2019
Document type:
Article
Affiliation country: