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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.
Carbone, Michele; Amelio, Ivano; Affar, El Bachir; Brugarolas, James; Cannon-Albright, Lisa A; Cantley, Lewis C; Cavenee, Webster K; Chen, Zhijian; Croce, Carlo M; Andrea, Alan D'; Gandara, David; Giorgi, Carlotta; Jia, Wei; Lan, Qing; Mak, Tak Wah; Manley, James L; Mikoshiba, Katsuhiko; Onuchic, Jose N; Pass, Harvey I; Pinton, Paolo; Prives, Carol; Rothman, Nathaniel; Sebti, Said M; Turkson, James; Wu, Xifeng; Yang, Haining; Yu, Herbert; Melino, Gerry.
Affiliation
  • Carbone M; Hawaii Cancer Center, Honolulu, HI, USA. mcarbone@cc.hawaii.edu.
  • Amelio I; MRC Toxicology Unit, Leicester, UK.
  • Affar EB; Department of Medicine, Maisonneuve-Rosemont Hospital Research Center, University of Montréal, Montréal, Quebec, H1T 2M4, Canada.
  • Brugarolas J; Department of Internal Medicine, Hematology-Oncology Division, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Cannon-Albright LA; Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA.
  • Cantley LC; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.
  • Cavenee WK; Meyer Cancer Center, Weill Cornell Medical College, 413 E. 69(th) Street, New York, NY, 10021, USA.
  • Chen Z; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, 92093, USA.
  • Croce CM; Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Andrea A; Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Gandara D; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
  • Giorgi C; Thoracic Oncology, UC Davis, Sacramento, CA, 96817, USA.
  • Jia W; Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
  • Lan Q; Hawaii Cancer Center, Honolulu, HI, USA.
  • Mak TW; Occupational & Environmental Epidemiology Branch Division of Cancer Epidemiology & Genetics National Cancer Institute NIH, Bethesda, MD, USA.
  • Manley JL; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, ON, M5G 2M9, Canada.
  • Mikoshiba K; Department of Biological Sciences, Columbia University, New York, NY, USA.
  • Onuchic JN; Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan.
  • Pass HI; Center for Theoretical Biological Physics, Rice University, Houston, TX, 77005, USA.
  • Pinton P; Division of General Thoracic Surgery, Department of Cardiothoracic Surgery, NYU Langone Medical Center, New York, NY, USA.
  • Prives C; Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
  • Rothman N; Department of Biological Sciences, Columbia University, New York, New York, 10027, USA.
  • Sebti SM; Occupational & Environmental Epidemiology Branch Division of Cancer Epidemiology & Genetics National Cancer Institute NIH, Bethesda, MD, USA.
  • Turkson J; Drug Discovery Department, Moffitt Cancer Center, and Department of Oncologic Sciences, University of South Florida, Tampa, FL, 33612, USA.
  • Wu X; Hawaii Cancer Center, Honolulu, HI, USA.
  • Yang H; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Yu H; Hawaii Cancer Center, Honolulu, HI, USA.
  • Melino G; Hawaii Cancer Center, Honolulu, HI, USA.
Cell Death Differ ; 25(11): 1885-1904, 2018 11.
Article in En | MEDLINE | ID: mdl-30323273
ABSTRACT
The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue. Gene-environment interactions (G x E) arise when the combined presence of both a germline genetic variant and a known environmental factor modulates the risk of disease more than either one alone. A panel of experts discussed our current understanding of cancer aetiology, known examples of G × E interactions in cancer, and the expanded concept of G × E interactions to include somatic cancer mutations and iatrogenic environmental factors such as anti-cancer treatment. Specific genetic polymorphisms and genetic mutations increase susceptibility to certain carcinogens and may be targeted in the near future for prevention and treatment of cancer patients with novel molecularly based therapies. There was general consensus that a better understanding of the complexity and numerosity of G × E interactions, supported by adequate technological, epidemiological, modelling and statistical resources, will further promote our understanding of cancer and lead to novel preventive and therapeutic approaches.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precision Medicine / Gene-Environment Interaction / Neoplasms Type of study: Guideline / Prognostic_studies Limits: Humans Language: En Journal: Cell Death Differ Year: 2018 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precision Medicine / Gene-Environment Interaction / Neoplasms Type of study: Guideline / Prognostic_studies Limits: Humans Language: En Journal: Cell Death Differ Year: 2018 Document type: Article Affiliation country: